AMESON PDRN PLUS Microneedling: A New Way to Make Skin Look Young

Why Are Clinics Turning to AMESON PDRN PLUS Microneedling for Next-Generation Skin Rejuvenation
The aesthetics industry is rapidly evolving. Today’s clients are no longer satisfied with superficial or injectable treatments – that just simply mask the signs of ageing: or have no real role in a true anti-ageing process. Clients are now seeking science-backed solutions that stimulate REAL skin regeneration.
by Angela Hodgkiss
What is PDRN?
For professional clinics looking to differentiate themselves in an increasingly competitive market, AMESON PDRN combined with microneedling, provides an opportunity to introduce a treatment that is innovative, clinically supported and validated since 1989, and is highly results-driven.
PDRN (Poly-deoxy-ribo-nucleotide) is a purified chain of DNA fragments derived from salmon reproductive cells, selected, because it is exceptionally rich in nucleotides—the building blocks of cellular repair for every living organism. These PDRN fragments are highly biocompatible with human tissue, sharing over 95% similarity with human DNA, while remaining biologically safe and non-immunogenic.
It is important to note that all living things: plant, human, animal, bacteria, fungi etc, ALL, share the same four nucleotides: Adenine, Thymine, Guanine and Cytosine, however, the way the chains are sequenced, makes all the difference, between a human with legs and a salmon with gills! Also important to note, is that the PDRN fragments can never alter or disturb our own human DNA coding.
Why Microneedling Is the Perfect Delivery System?
One of AMESON PDRN’s primary mechanisms is the activation of adenosine A2A receptors within the dermis. This activation triggers a cascade of regenerative responses, including:
- Increased fibroblast activity
- Enhanced collagen and elastin production
- Improved microcirculation
- Reduced inflammation
- Accelerated tissue repair
In addition, PDRN interacts with TLR-9 receptors in keratinocytes and immune cells, helping activate the skin’s natural wound-healing response
Whilst AMESON PDRN can be applied topically, its results are significantly enhanced, when combined with professional microneedling treatments: combining two proven technologies and creating a synergistic treatment approach that surpasses what either modality could achieve independently.
Microneedling creates controlled microchannels in the skin that:
- Stimulates the natural wound-healing process
- Triggers collagen and elastin production
- Enhances the penetration of active ingredients
The result is a synergistic regenerative therapy that improves:
- Skin firmness
- Hydration
- Fine lines and wrinkles
- Overall texture and radiance
This flexibility allows clinics to treat multiple skin concerns with a single regenerative platform.

AMESON PDRN Microneedling is a Treatment That Builds Long-Term Client Loyalty
Unlike treatments that deliver only temporary results, AMESON PDRN works in partnership with the skin’s natural biology, producing improvements that continue to develop over time.
Most treatment protocols involve:
- 3–4 initial treatments
- Spaced 4-8 weeks apart
- Maintenance sessions every 3 months help maintain optimal skin quality
If you are interested in introducing this advanced treatment to your clinic, we would love to discuss how we can support your team with:
- Professional training
- Treatment protocols
- Marketing support